Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1736717..1738412 Replicon chromosome
Accession NZ_CP124649
Organism Pseudomonas aeruginosa strain 2020CK-00218

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I80_RS08165 Protein ID WP_023095293.1
Coordinates 1736717..1737586 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I80_RS08170 Protein ID WP_003112902.1
Coordinates 1737579..1738412 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I80_RS08140 (P7I80_08140) 1732725..1733576 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
P7I80_RS08145 (P7I80_08145) 1733617..1734624 + 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I80_RS08150 (P7I80_08150) 1734621..1735397 + 777 WP_003112898.1 ABC transporter permease -
P7I80_RS08155 (P7I80_08155) 1735403..1736164 + 762 WP_003112899.1 SDR family oxidoreductase -
P7I80_RS08160 (P7I80_08160) 1736178..1736708 + 531 WP_003112900.1 cupin domain-containing protein -
P7I80_RS08165 (P7I80_08165) 1736717..1737586 + 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I80_RS08170 (P7I80_08170) 1737579..1738412 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I80_RS08175 (P7I80_08175) 1738399..1739196 + 798 WP_282393612.1 SDR family oxidoreductase -
P7I80_RS08180 (P7I80_08180) 1739189..1740871 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
P7I80_RS08185 (P7I80_08185) 1740882..1741685 + 804 WP_003112905.1 aspartate dehydrogenase -
P7I80_RS08190 (P7I80_08190) 1741697..1743181 + 1485 WP_022579701.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280944 WP_023095293.1 NZ_CP124649:1736717-1737586 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280944 WP_003112902.1 NZ_CP124649:1737579-1738412 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References