Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143407..143912 Replicon chromosome
Accession NZ_CP124649
Organism Pseudomonas aeruginosa strain 2020CK-00218

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I80_RS00665 Protein ID WP_003083773.1
Coordinates 143407..143688 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I80_RS00670 Protein ID WP_003083775.1
Coordinates 143685..143912 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I80_RS00640 (P7I80_00640) 138658..140007 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I80_RS00645 (P7I80_00645) 140056..140742 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I80_RS00650 (P7I80_00650) 140843..141577 + 735 WP_003083764.1 GntR family transcriptional regulator -
P7I80_RS00655 (P7I80_00655) 141757..142167 + 411 WP_003110659.1 aegerolysin family protein -
P7I80_RS00660 (P7I80_00660) 142199..143107 - 909 WP_003083769.1 LysR family transcriptional regulator -
P7I80_RS00665 (P7I80_00665) 143407..143688 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I80_RS00670 (P7I80_00670) 143685..143912 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I80_RS00675 (P7I80_00675) 144088..144708 - 621 WP_003101226.1 hypothetical protein -
P7I80_RS00680 (P7I80_00680) 144809..145309 + 501 WP_003083778.1 LEA type 2 family protein -
P7I80_RS00685 (P7I80_00685) 145382..145723 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
P7I80_RS00690 (P7I80_00690) 145807..147234 - 1428 WP_003083784.1 GABA permease -
P7I80_RS00695 (P7I80_00695) 147403..148896 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280943 WP_003083773.1 NZ_CP124649:c143688-143407 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280943 WP_003083775.1 NZ_CP124649:c143912-143685 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References