Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 6071870..6073091 Replicon chromosome
Accession NZ_CP124648
Organism Pseudomonas aeruginosa strain 2020CK-00220

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I81_RS28325 Protein ID WP_003110488.1
Coordinates 6072513..6073091 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I81_RS28320 Protein ID WP_003132728.1
Coordinates 6071870..6072424 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I81_RS28295 (P7I81_28295) 6067436..6067987 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I81_RS28300 (P7I81_28300) 6067984..6068382 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I81_RS28305 (P7I81_28305) 6068395..6068718 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I81_RS28310 (P7I81_28310) 6069049..6069510 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
P7I81_RS28315 (P7I81_28315) 6069515..6071710 + 2196 WP_024947749.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I81_RS28320 (P7I81_28320) 6071870..6072424 + 555 WP_003132728.1 helix-turn-helix transcriptional regulator Antitoxin
P7I81_RS28325 (P7I81_28325) 6072513..6073091 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I81_RS28330 (P7I81_28330) 6073201..6074388 - 1188 WP_003132729.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I81_RS28335 (P7I81_28335) 6074378..6076549 - 2172 WP_003132730.1 type I secretion system permease/ATPase -
P7I81_RS28340 (P7I81_28340) 6076539..6077816 - 1278 Protein_5594 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280942 WP_003110488.1 NZ_CP124648:6072513-6073091 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT280942 WP_003132728.1 NZ_CP124648:6071870-6072424 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References