Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Acetyltransf_4(toxin) |
Location | 4394213..4395721 | Replicon | chromosome |
Accession | NZ_CP124648 | ||
Organism | Pseudomonas aeruginosa strain 2020CK-00220 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9HYX1 |
Locus tag | P7I81_RS20600 | Protein ID | WP_003119682.1 |
Coordinates | 4394213..4394800 (+) | Length | 196 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | - |
Locus tag | P7I81_RS20605 | Protein ID | WP_124090262.1 |
Coordinates | 4394867..4395721 (+) | Length | 285 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I81_RS20595 (P7I81_20595) | 4390468..4393947 | - | 3480 | WP_003091610.1 | PAS domain-containing hybrid sensor histidine kinase/response regulator | - |
P7I81_RS20600 (P7I81_20600) | 4394213..4394800 | + | 588 | WP_003119682.1 | GNAT family protein | Toxin |
P7I81_RS20605 (P7I81_20605) | 4394867..4395721 | + | 855 | WP_124090262.1 | AraC family transcriptional regulator | Antitoxin |
P7I81_RS20610 (P7I81_20610) | 4395818..4397983 | + | 2166 | WP_134438643.1 | TonB-dependent receptor family protein | - |
P7I81_RS20615 (P7I81_20615) | 4398158..4400032 | + | 1875 | WP_003091605.1 | MFS transporter | - |
P7I81_RS20620 (P7I81_20620) | 4400093..4400302 | - | 210 | WP_003091604.1 | cold-shock protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 196 a.a. Molecular weight: 21901.23 Da Isoelectric Point: 9.8676
>T280941 WP_003119682.1 NZ_CP124648:4394213-4394800 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG
Download Length: 588 bp
Antitoxin
Download Length: 285 a.a. Molecular weight: 31822.10 Da Isoelectric Point: 7.3038
>AT280941 WP_124090262.1 NZ_CP124648:4394867-4395721 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVYLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACAGSSLTTYE
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVYLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACAGSSLTTYE
Download Length: 855 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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