Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4394213..4395721 Replicon chromosome
Accession NZ_CP124648
Organism Pseudomonas aeruginosa strain 2020CK-00220

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I81_RS20600 Protein ID WP_003119682.1
Coordinates 4394213..4394800 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag P7I81_RS20605 Protein ID WP_124090262.1
Coordinates 4394867..4395721 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I81_RS20595 (P7I81_20595) 4390468..4393947 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
P7I81_RS20600 (P7I81_20600) 4394213..4394800 + 588 WP_003119682.1 GNAT family protein Toxin
P7I81_RS20605 (P7I81_20605) 4394867..4395721 + 855 WP_124090262.1 AraC family transcriptional regulator Antitoxin
P7I81_RS20610 (P7I81_20610) 4395818..4397983 + 2166 WP_134438643.1 TonB-dependent receptor family protein -
P7I81_RS20615 (P7I81_20615) 4398158..4400032 + 1875 WP_003091605.1 MFS transporter -
P7I81_RS20620 (P7I81_20620) 4400093..4400302 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280941 WP_003119682.1 NZ_CP124648:4394213-4394800 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31822.10 Da        Isoelectric Point: 7.3038

>AT280941 WP_124090262.1 NZ_CP124648:4394867-4395721 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVYLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACAGSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References