280938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 868004..868612 Replicon chromosome
Accession NZ_CP124648
Organism Pseudomonas aeruginosa strain 2020CK-00220

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag P7I81_RS04200 Protein ID WP_019486378.1
Coordinates 868004..868351 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag P7I81_RS04205 Protein ID WP_003114155.1
Coordinates 868361..868612 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I81_RS04170 (P7I81_04170) 863423..863635 + 213 WP_003085460.1 cysteine-rich CWC family protein -
P7I81_RS04175 (P7I81_04175) 863635..864327 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
P7I81_RS04180 (P7I81_04180) 864463..865506 + 1044 WP_003110811.1 L,D-transpeptidase -
P7I81_RS04185 (P7I81_04185) 865586..866323 + 738 WP_023130192.1 murein L,D-transpeptidase catalytic domain family protein -
P7I81_RS04190 (P7I81_04190) 866775..867677 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
P7I81_RS04200 (P7I81_04200) 868004..868351 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I81_RS04205 (P7I81_04205) 868361..868612 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P7I81_RS04210 (P7I81_04210) 868826..869809 - 984 WP_058174561.1 tyrosine-type recombinase/integrase -
P7I81_RS04215 (P7I81_04215) 869809..871101 - 1293 WP_100212560.1 hypothetical protein -
P7I81_RS04220 (P7I81_04220) 871359..872621 - 1263 WP_034049230.1 zonular occludens toxin domain-containing protein -
P7I81_RS04225 (P7I81_04225) 872623..872973 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 868004..890529 22525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T280938 WP_019486378.1 NZ_CP124648:c868351-868004 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT280938 WP_003114155.1 NZ_CP124648:c868612-868361 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References