280937

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 546425..547684 Replicon chromosome
Accession NZ_CP124648
Organism Pseudomonas aeruginosa strain 2020CK-00220

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag P7I81_RS02605 Protein ID WP_031636480.1
Coordinates 546425..547180 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I81_RS02610 Protein ID WP_003086329.1
Coordinates 547316..547684 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I81_RS02595 (P7I81_02595) 541596..544139 + 2544 WP_124089405.1 acyl-homoserine-lactone acylase QuiP -
P7I81_RS02600 (P7I81_02600) 544294..545655 - 1362 WP_003134034.1 DNA recombination protein RmuC -
P7I81_RS02605 (P7I81_02605) 546425..547180 - 756 WP_031636480.1 RES family NAD+ phosphorylase Toxin
P7I81_RS02610 (P7I81_02610) 547316..547684 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I81_RS02615 (P7I81_02615) 547757..549043 - 1287 WP_124089406.1 FAD-binding oxidoreductase -
P7I81_RS02620 (P7I81_02620) 549099..550592 - 1494 WP_031693435.1 aldehyde dehydrogenase family protein -
P7I81_RS02625 (P7I81_02625) 550767..551243 + 477 WP_003086322.1 hypothetical protein -
P7I81_RS02630 (P7I81_02630) 551246..551521 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.36 Da        Isoelectric Point: 7.7297

>T280937 WP_031636480.1 NZ_CP124648:c547180-546425 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALRLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280937 WP_003086329.1 NZ_CP124648:c547684-547316 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References