Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 6698012..6698610 Replicon chromosome
Accession NZ_CP124646
Organism Pseudomonas aeruginosa strain 2020CK-00185

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag P7I78_RS31190 Protein ID WP_048388330.1
Coordinates 6698012..6698314 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I78_RS31195 Protein ID WP_042857721.1
Coordinates 6698311..6698610 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I78_RS31160 (P7I78_31160) 6694336..6694578 - 243 WP_047303031.1 hypothetical protein -
P7I78_RS31165 (P7I78_31165) 6694725..6695816 - 1092 WP_282415508.1 hypothetical protein -
P7I78_RS31170 (P7I78_31170) 6695882..6696100 - 219 WP_047303033.1 hypothetical protein -
P7I78_RS31175 (P7I78_31175) 6696157..6696474 - 318 WP_047303035.1 hypothetical protein -
P7I78_RS31180 (P7I78_31180) 6696507..6696875 - 369 WP_047303037.1 hypothetical protein -
P7I78_RS31185 (P7I78_31185) 6697029..6697808 - 780 WP_182330310.1 DUF4942 domain-containing protein -
P7I78_RS31190 (P7I78_31190) 6698012..6698314 + 303 WP_048388330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I78_RS31195 (P7I78_31195) 6698311..6698610 + 300 WP_042857721.1 putative addiction module antidote protein Antitoxin
P7I78_RS31200 (P7I78_31200) 6698633..6698956 + 324 WP_048388333.1 hypothetical protein -
P7I78_RS31205 (P7I78_31205) 6698969..6699190 + 222 WP_048388335.1 hypothetical protein -
P7I78_RS31210 (P7I78_31210) 6699192..6699509 + 318 WP_152690486.1 hypothetical protein -
P7I78_RS31215 (P7I78_31215) 6700618..6700893 - 276 WP_134286862.1 hypothetical protein -
P7I78_RS31220 (P7I78_31220) 6700922..6701875 - 954 WP_052960123.1 non-homologous end-joining DNA ligase -
P7I78_RS31225 (P7I78_31225) 6702014..6702445 + 432 WP_047306860.1 translesion error-prone DNA polymerase V autoproteolytic subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaIMP-15 / blaOXA-2 / catB2 - 6640653..6900395 259742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(6-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11261.85 Da        Isoelectric Point: 10.3903

>T280935 WP_048388330.1 NZ_CP124646:6698012-6698314 [Pseudomonas aeruginosa]
MKTIKQTATYRNWERKLRDKQAKAIIAARVFRVAHGLLGDVQPVGQGISELRIHHGPGYRVYFQQRGNQLVLLLCGGDKS
SQARDIETAKALASQWSDDE

Download         Length: 303 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10853.33 Da        Isoelectric Point: 5.1084

>AT280935 WP_042857721.1 NZ_CP124646:6698311-6698610 [Pseudomonas aeruginosa]
MKEQFYDYDPADALTDAESIAVFMEDAFETGDAAYIAKCLGVVARAKGMTALANESGLSREHLYRSFSDKGNPTLKTLLA
VMRAVGLDLTTRKHVEPVH

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References