Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3141723..3142943 Replicon chromosome
Accession NZ_CP124646
Organism Pseudomonas aeruginosa strain 2020CK-00185

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I78_RS14820 Protein ID WP_003110488.1
Coordinates 3141723..3142301 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I78_RS14825 Protein ID WP_003088112.1
Coordinates 3142389..3142943 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I78_RS14805 (P7I78_14805) 3136999..3138276 + 1278 WP_003139889.1 TolC family protein -
P7I78_RS14810 (P7I78_14810) 3138266..3140437 + 2172 WP_003139887.1 type I secretion system permease/ATPase -
P7I78_RS14815 (P7I78_14815) 3140427..3141614 + 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I78_RS14820 (P7I78_14820) 3141723..3142301 - 579 WP_003110488.1 HD domain-containing protein Toxin
P7I78_RS14825 (P7I78_14825) 3142389..3142943 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I78_RS14830 (P7I78_14830) 3143101..3145296 - 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I78_RS14835 (P7I78_14835) 3145301..3145762 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I78_RS14840 (P7I78_14840) 3146093..3146416 + 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I78_RS14845 (P7I78_14845) 3146429..3146827 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I78_RS14850 (P7I78_14850) 3146824..3147375 - 552 WP_003139878.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280931 WP_003110488.1 NZ_CP124646:c3142301-3141723 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280931 WP_003088112.1 NZ_CP124646:c3142943-3142389 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References