Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3141723..3142943 | Replicon | chromosome |
Accession | NZ_CP124646 | ||
Organism | Pseudomonas aeruginosa strain 2020CK-00185 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | P7I78_RS14820 | Protein ID | WP_003110488.1 |
Coordinates | 3141723..3142301 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | P7I78_RS14825 | Protein ID | WP_003088112.1 |
Coordinates | 3142389..3142943 (-) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I78_RS14805 (P7I78_14805) | 3136999..3138276 | + | 1278 | WP_003139889.1 | TolC family protein | - |
P7I78_RS14810 (P7I78_14810) | 3138266..3140437 | + | 2172 | WP_003139887.1 | type I secretion system permease/ATPase | - |
P7I78_RS14815 (P7I78_14815) | 3140427..3141614 | + | 1188 | WP_003139884.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
P7I78_RS14820 (P7I78_14820) | 3141723..3142301 | - | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
P7I78_RS14825 (P7I78_14825) | 3142389..3142943 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
P7I78_RS14830 (P7I78_14830) | 3143101..3145296 | - | 2196 | WP_003139882.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
P7I78_RS14835 (P7I78_14835) | 3145301..3145762 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
P7I78_RS14840 (P7I78_14840) | 3146093..3146416 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
P7I78_RS14845 (P7I78_14845) | 3146429..3146827 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
P7I78_RS14850 (P7I78_14850) | 3146824..3147375 | - | 552 | WP_003139878.1 | XRE family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T280931 WP_003110488.1 NZ_CP124646:c3142301-3141723 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280931 WP_003088112.1 NZ_CP124646:c3142943-3142389 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|