Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 2198494..2199752 | Replicon | chromosome |
| Accession | NZ_CP124646 | ||
| Organism | Pseudomonas aeruginosa strain 2020CK-00185 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A0H2Z7F3 |
| Locus tag | P7I78_RS10410 | Protein ID | WP_003140635.1 |
| Coordinates | 2198997..2199752 (+) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | P7I78_RS10405 | Protein ID | WP_003086329.1 |
| Coordinates | 2198494..2198862 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I78_RS10385 (P7I78_10385) | 2194657..2194932 | + | 276 | WP_023098713.1 | zinc ribbon domain-containing protein | - |
| P7I78_RS10390 (P7I78_10390) | 2194935..2195411 | - | 477 | WP_003140638.1 | hypothetical protein | - |
| P7I78_RS10395 (P7I78_10395) | 2195586..2197079 | + | 1494 | WP_016254122.1 | aldehyde dehydrogenase family protein | - |
| P7I78_RS10400 (P7I78_10400) | 2197135..2198421 | + | 1287 | WP_003086327.1 | FAD-binding oxidoreductase | - |
| P7I78_RS10405 (P7I78_10405) | 2198494..2198862 | + | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| P7I78_RS10410 (P7I78_10410) | 2198997..2199752 | + | 756 | WP_003140635.1 | RES family NAD+ phosphorylase | Toxin |
| P7I78_RS10415 (P7I78_10415) | 2200522..2201883 | + | 1362 | WP_003081943.1 | DNA recombination protein RmuC | - |
| P7I78_RS10420 (P7I78_10420) | 2202038..2204581 | - | 2544 | WP_003140632.1 | acyl-homoserine-lactone acylase QuiP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28220.34 Da Isoelectric Point: 7.7294
>T280930 WP_003140635.1 NZ_CP124646:2198997-2199752 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT280930 WP_003086329.1 NZ_CP124646:2198494-2198862 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2Z7F3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V6AJU7 |