Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2198494..2199752 Replicon chromosome
Accession NZ_CP124646
Organism Pseudomonas aeruginosa strain 2020CK-00185

Toxin (Protein)


Gene name - Uniprot ID A0A0H2Z7F3
Locus tag P7I78_RS10410 Protein ID WP_003140635.1
Coordinates 2198997..2199752 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I78_RS10405 Protein ID WP_003086329.1
Coordinates 2198494..2198862 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I78_RS10385 (P7I78_10385) 2194657..2194932 + 276 WP_023098713.1 zinc ribbon domain-containing protein -
P7I78_RS10390 (P7I78_10390) 2194935..2195411 - 477 WP_003140638.1 hypothetical protein -
P7I78_RS10395 (P7I78_10395) 2195586..2197079 + 1494 WP_016254122.1 aldehyde dehydrogenase family protein -
P7I78_RS10400 (P7I78_10400) 2197135..2198421 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I78_RS10405 (P7I78_10405) 2198494..2198862 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I78_RS10410 (P7I78_10410) 2198997..2199752 + 756 WP_003140635.1 RES family NAD+ phosphorylase Toxin
P7I78_RS10415 (P7I78_10415) 2200522..2201883 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I78_RS10420 (P7I78_10420) 2202038..2204581 - 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28220.34 Da        Isoelectric Point: 7.7294

>T280930 WP_003140635.1 NZ_CP124646:2198997-2199752 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280930 WP_003086329.1 NZ_CP124646:2198494-2198862 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z7F3

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References