Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4902284..4902892 Replicon chromosome
Accession NZ_CP124641
Organism Pseudomonas aeruginosa strain 2021CK-01198

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag P7I90_RS22850 Protein ID WP_019486378.1
Coordinates 4902284..4902631 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag P7I90_RS22855 Protein ID WP_003114155.1
Coordinates 4902641..4902892 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I90_RS22820 (P7I90_22820) 4897703..4897915 + 213 WP_023112330.1 cysteine-rich CWC family protein -
P7I90_RS22825 (P7I90_22825) 4897915..4898607 + 693 WP_022579823.1 16S rRNA pseudouridine(516) synthase -
P7I90_RS22830 (P7I90_22830) 4898743..4899786 + 1044 WP_003110811.1 L,D-transpeptidase -
P7I90_RS22835 (P7I90_22835) 4899866..4900603 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
P7I90_RS22840 (P7I90_22840) 4901055..4901957 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
P7I90_RS22850 (P7I90_22850) 4902284..4902631 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I90_RS22855 (P7I90_22855) 4902641..4902892 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P7I90_RS22860 (P7I90_22860) 4903106..4904089 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
P7I90_RS22865 (P7I90_22865) 4904089..4905379 - 1291 Protein_4524 hypothetical protein -
P7I90_RS22870 (P7I90_22870) 4905638..4906900 - 1263 WP_003133724.1 zonular occludens toxin domain-containing protein -
P7I90_RS22875 (P7I90_22875) 4906902..4907252 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4902284..4919290 17006
- inside Prophage catB7 - 4893209..4927554 34345


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T280924 WP_019486378.1 NZ_CP124641:c4902631-4902284 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT280924 WP_003114155.1 NZ_CP124641:c4902892-4902641 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References