Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4507869..4509127 Replicon chromosome
Accession NZ_CP124641
Organism Pseudomonas aeruginosa strain 2021CK-01198

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I90_RS20835 Protein ID WP_003086331.1
Coordinates 4507869..4508624 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I90_RS20840 Protein ID WP_003086329.1
Coordinates 4508759..4509127 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I90_RS20825 (P7I90_20825) 4503040..4505583 + 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -
P7I90_RS20830 (P7I90_20830) 4505738..4507099 - 1362 WP_073647918.1 DNA recombination protein RmuC -
P7I90_RS20835 (P7I90_20835) 4507869..4508624 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I90_RS20840 (P7I90_20840) 4508759..4509127 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I90_RS20845 (P7I90_20845) 4509200..4510486 - 1287 WP_031756378.1 FAD-binding oxidoreductase -
P7I90_RS20850 (P7I90_20850) 4510542..4512036 - 1495 Protein_4129 aldehyde dehydrogenase family protein -
P7I90_RS20855 (P7I90_20855) 4512211..4512687 + 477 WP_003086322.1 hypothetical protein -
P7I90_RS20860 (P7I90_20860) 4512690..4512965 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280923 WP_003086331.1 NZ_CP124641:c4508624-4507869 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280923 WP_003086329.1 NZ_CP124641:c4509127-4508759 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References