Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3547319..3548539 Replicon chromosome
Accession NZ_CP124641
Organism Pseudomonas aeruginosa strain 2021CK-01198

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I90_RS16345 Protein ID WP_003110488.1
Coordinates 3547961..3548539 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I90_RS16340 Protein ID WP_003088112.1
Coordinates 3547319..3547873 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I90_RS16315 (P7I90_16315) 3542887..3543438 + 552 WP_003132721.1 XRE family transcriptional regulator -
P7I90_RS16320 (P7I90_16320) 3543435..3543833 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I90_RS16325 (P7I90_16325) 3543846..3544169 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I90_RS16330 (P7I90_16330) 3544500..3544961 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I90_RS16335 (P7I90_16335) 3544966..3547161 + 2196 WP_023097736.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I90_RS16340 (P7I90_16340) 3547319..3547873 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I90_RS16345 (P7I90_16345) 3547961..3548539 + 579 WP_003110488.1 HD domain-containing protein Toxin
P7I90_RS16350 (P7I90_16350) 3548648..3549835 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I90_RS16355 (P7I90_16355) 3549825..3551996 - 2172 WP_096248773.1 type I secretion system permease/ATPase -
P7I90_RS16360 (P7I90_16360) 3551986..3553263 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280922 WP_003110488.1 NZ_CP124641:3547961-3548539 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280922 WP_003088112.1 NZ_CP124641:3547319-3547873 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References