Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147843..148348 Replicon chromosome
Accession NZ_CP124641
Organism Pseudomonas aeruginosa strain 2021CK-01198

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I90_RS00655 Protein ID WP_003083773.1
Coordinates 147843..148124 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I90_RS00660 Protein ID WP_003083775.1
Coordinates 148121..148348 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I90_RS00630 (P7I90_00630) 143094..144443 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I90_RS00635 (P7I90_00635) 144492..145178 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I90_RS00640 (P7I90_00640) 145279..146013 + 735 WP_003110658.1 GntR family transcriptional regulator -
P7I90_RS00645 (P7I90_00645) 146193..146603 + 411 WP_003110659.1 aegerolysin family protein -
P7I90_RS00650 (P7I90_00650) 146635..147543 - 909 WP_003083769.1 LysR family transcriptional regulator -
P7I90_RS00655 (P7I90_00655) 147843..148124 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I90_RS00660 (P7I90_00660) 148121..148348 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I90_RS00665 (P7I90_00665) 148524..149144 - 621 WP_003101226.1 hypothetical protein -
P7I90_RS00670 (P7I90_00670) 149245..149745 + 501 WP_003162763.1 LEA type 2 family protein -
P7I90_RS00675 (P7I90_00675) 149818..150159 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
P7I90_RS00680 (P7I90_00680) 150241..151668 - 1428 WP_003083784.1 GABA permease -
P7I90_RS00685 (P7I90_00685) 151837..153330 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280920 WP_003083773.1 NZ_CP124641:c148124-147843 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280920 WP_003083775.1 NZ_CP124641:c148348-148121 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References