Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4902344..4902952 Replicon chromosome
Accession NZ_CP124638
Organism Pseudomonas aeruginosa strain 2021CK-01158

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag P7I84_RS22860 Protein ID WP_019486378.1
Coordinates 4902344..4902691 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag P7I84_RS22865 Protein ID WP_003114155.1
Coordinates 4902701..4902952 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I84_RS22830 (P7I84_22840) 4897763..4897975 + 213 WP_023112330.1 cysteine-rich CWC family protein -
P7I84_RS22835 (P7I84_22845) 4897975..4898667 + 693 WP_022579823.1 16S rRNA pseudouridine(516) synthase -
P7I84_RS22840 (P7I84_22850) 4898803..4899846 + 1044 WP_003110811.1 L,D-transpeptidase -
P7I84_RS22845 (P7I84_22855) 4899926..4900663 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
P7I84_RS22850 (P7I84_22860) 4901115..4902017 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
P7I84_RS22860 (P7I84_22870) 4902344..4902691 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I84_RS22865 (P7I84_22875) 4902701..4902952 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P7I84_RS22870 (P7I84_22880) 4903166..4904149 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
P7I84_RS22875 (P7I84_22885) 4904149..4905439 - 1291 Protein_4526 hypothetical protein -
P7I84_RS22880 (P7I84_22890) 4905698..4906960 - 1263 WP_003133724.1 zonular occludens toxin domain-containing protein -
P7I84_RS22885 (P7I84_22895) 4906962..4907312 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4902344..4919350 17006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T280917 WP_019486378.1 NZ_CP124638:c4902691-4902344 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT280917 WP_003114155.1 NZ_CP124638:c4902952-4902701 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References