280916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4379977..4381485 Replicon chromosome
Accession NZ_CP124638
Organism Pseudomonas aeruginosa strain 2021CK-01158

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I84_RS20265 Protein ID WP_003119682.1
Coordinates 4380898..4381485 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag P7I84_RS20260 Protein ID WP_003091607.1
Coordinates 4379977..4380831 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I84_RS20245 (P7I84_20250) 4375397..4375606 + 210 WP_003091604.1 cold-shock protein -
P7I84_RS20250 (P7I84_20255) 4375666..4377540 - 1875 WP_003091605.1 MFS transporter -
P7I84_RS20255 (P7I84_20260) 4377715..4379880 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
P7I84_RS20260 (P7I84_20265) 4379977..4380831 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
P7I84_RS20265 (P7I84_20270) 4380898..4381485 - 588 WP_003119682.1 GNAT family protein Toxin
P7I84_RS20270 (P7I84_20275) 4381750..4385229 + 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280916 WP_003119682.1 NZ_CP124638:c4381485-4380898 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT280916 WP_003091607.1 NZ_CP124638:c4380831-4379977 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References