280915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2742647..2743867 Replicon chromosome
Accession NZ_CP124638
Organism Pseudomonas aeruginosa strain 2021CK-01158

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P7I84_RS12910 Protein ID WP_003110488.1
Coordinates 2742647..2743225 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P7I84_RS12915 Protein ID WP_003088112.1
Coordinates 2743313..2743867 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I84_RS12895 (P7I84_12900) 2737923..2739200 + 1278 WP_003088104.1 TolC family protein -
P7I84_RS12900 (P7I84_12905) 2739190..2741361 + 2172 WP_096248773.1 type I secretion system permease/ATPase -
P7I84_RS12905 (P7I84_12910) 2741351..2742538 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
P7I84_RS12910 (P7I84_12915) 2742647..2743225 - 579 WP_003110488.1 HD domain-containing protein Toxin
P7I84_RS12915 (P7I84_12920) 2743313..2743867 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P7I84_RS12920 (P7I84_12925) 2744025..2746220 - 2196 WP_023097736.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P7I84_RS12925 (P7I84_12930) 2746225..2746686 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
P7I84_RS12930 (P7I84_12935) 2747017..2747340 + 324 WP_003102734.1 multidrug efflux SMR transporter -
P7I84_RS12935 (P7I84_12940) 2747353..2747751 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P7I84_RS12940 (P7I84_12945) 2747748..2748299 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T280915 WP_003110488.1 NZ_CP124638:c2743225-2742647 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280915 WP_003088112.1 NZ_CP124638:c2743867-2743313 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References