280914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1782225..1783483 Replicon chromosome
Accession NZ_CP124638
Organism Pseudomonas aeruginosa strain 2021CK-01158

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I84_RS08420 Protein ID WP_003086331.1
Coordinates 1782728..1783483 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I84_RS08415 Protein ID WP_003086329.1
Coordinates 1782225..1782593 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I84_RS08395 (P7I84_08400) 1778388..1778663 + 276 WP_023098713.1 zinc ribbon domain-containing protein -
P7I84_RS08400 (P7I84_08405) 1778666..1779142 - 477 WP_003086322.1 hypothetical protein -
P7I84_RS08405 (P7I84_08410) 1779317..1780810 + 1494 WP_033990296.1 aldehyde dehydrogenase family protein -
P7I84_RS08410 (P7I84_08415) 1780866..1782152 + 1287 WP_031756378.1 FAD-binding oxidoreductase -
P7I84_RS08415 (P7I84_08420) 1782225..1782593 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I84_RS08420 (P7I84_08425) 1782728..1783483 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I84_RS08425 (P7I84_08430) 1784253..1785614 + 1362 WP_073647918.1 DNA recombination protein RmuC -
P7I84_RS08430 (P7I84_08435) 1785769..1788312 - 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280914 WP_003086331.1 NZ_CP124638:1782728-1783483 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280914 WP_003086329.1 NZ_CP124638:1782225-1782593 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References