280912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 49587..50173 Replicon plasmid unnamed1
Accession NZ_CP124633
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I87_RS35080 Protein ID WP_003120987.1
Coordinates 49587..49886 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I87_RS35085 Protein ID WP_003448662.1
Coordinates 49883..50173 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS35060 (P7I87_35060) 44701..45234 - 534 WP_023125174.1 type IV pilus biogenesis protein PilP -
P7I87_RS35065 (P7I87_35065) 45224..46549 - 1326 WP_023125173.1 type 4b pilus protein PilO2 -
P7I87_RS35070 (P7I87_35070) 46553..48262 - 1710 WP_023125172.1 PilN family type IVB pilus formation outer membrane protein -
P7I87_RS35075 (P7I87_35075) 48262..49385 - 1124 Protein_55 TcpQ domain-containing protein -
P7I87_RS35080 (P7I87_35080) 49587..49886 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I87_RS35085 (P7I87_35085) 49883..50173 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I87_RS35090 (P7I87_35090) 50256..50588 - 333 WP_031640358.1 hypothetical protein -
P7I87_RS35095 (P7I87_35095) 50585..50719 - 135 WP_033179080.1 hypothetical protein -
P7I87_RS35100 (P7I87_35100) 50729..52705 - 1977 WP_023125171.1 DEAD/DEAH box helicase -
P7I87_RS35105 (P7I87_35105) 52702..54597 - 1896 WP_031640357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82465 82465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280912 WP_003120987.1 NZ_CP124633:49587-49886 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280912 WP_003448662.1 NZ_CP124633:49883-50173 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References