Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6147767..6148353 Replicon chromosome
Accession NZ_CP124632
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I87_RS29330 Protein ID WP_003120987.1
Coordinates 6148054..6148353 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I87_RS29325 Protein ID WP_003448662.1
Coordinates 6147767..6148057 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS29305 (P7I87_29305) 6143343..6145238 + 1896 WP_031640357.1 hypothetical protein -
P7I87_RS29310 (P7I87_29310) 6145235..6147211 + 1977 WP_023125171.1 DEAD/DEAH box helicase -
P7I87_RS29315 (P7I87_29315) 6147221..6147355 + 135 WP_033179080.1 hypothetical protein -
P7I87_RS29320 (P7I87_29320) 6147352..6147684 + 333 WP_031640358.1 hypothetical protein -
P7I87_RS29325 (P7I87_29325) 6147767..6148057 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I87_RS29330 (P7I87_29330) 6148054..6148353 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I87_RS29335 (P7I87_29335) 6148555..6149678 + 1124 Protein_5803 TcpQ domain-containing protein -
P7I87_RS29340 (P7I87_29340) 6149678..6151387 + 1710 WP_023125172.1 PilN family type IVB pilus formation outer membrane protein -
P7I87_RS29345 (P7I87_29345) 6151391..6152716 + 1326 WP_023125173.1 type 4b pilus protein PilO2 -
P7I87_RS29350 (P7I87_29350) 6152706..6153239 + 534 WP_023125174.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 6120242..6202738 82496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280910 WP_003120987.1 NZ_CP124632:c6148353-6148054 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280910 WP_003448662.1 NZ_CP124632:c6148057-6147767 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References