280908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5354751..5356009 Replicon chromosome
Accession NZ_CP124632
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I87_RS25350 Protein ID WP_003086331.1
Coordinates 5354751..5355506 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I87_RS25355 Protein ID WP_003086329.1
Coordinates 5355641..5356009 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS25340 (P7I87_25340) 5349922..5352465 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
P7I87_RS25345 (P7I87_25345) 5352620..5353981 - 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I87_RS25350 (P7I87_25350) 5354751..5355506 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I87_RS25355 (P7I87_25355) 5355641..5356009 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I87_RS25360 (P7I87_25360) 5356082..5357368 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I87_RS25365 (P7I87_25365) 5357424..5358916 - 1493 Protein_5024 aldehyde dehydrogenase family protein -
P7I87_RS25370 (P7I87_25370) 5359091..5359567 + 477 WP_004353334.1 elongation factor GreAB -
P7I87_RS25375 (P7I87_25375) 5359570..5359830 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280908 WP_003086331.1 NZ_CP124632:c5355506-5354751 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280908 WP_003086329.1 NZ_CP124632:c5356009-5355641 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References