280906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3905362..3905948 Replicon chromosome
Accession NZ_CP124632
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I87_RS18495 Protein ID WP_003120987.1
Coordinates 3905362..3905661 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I87_RS18500 Protein ID WP_003448662.1
Coordinates 3905658..3905948 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS18475 (P7I87_18475) 3900476..3901009 - 534 WP_023125174.1 type IV pilus biogenesis protein PilP -
P7I87_RS18480 (P7I87_18480) 3900999..3902324 - 1326 WP_023125173.1 type 4b pilus protein PilO2 -
P7I87_RS18485 (P7I87_18485) 3902328..3904037 - 1710 WP_023125172.1 PilN family type IVB pilus formation outer membrane protein -
P7I87_RS18490 (P7I87_18490) 3904037..3905160 - 1124 Protein_3655 TcpQ domain-containing protein -
P7I87_RS18495 (P7I87_18495) 3905362..3905661 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I87_RS18500 (P7I87_18500) 3905658..3905948 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I87_RS18505 (P7I87_18505) 3906031..3906363 - 333 WP_031640358.1 hypothetical protein -
P7I87_RS18510 (P7I87_18510) 3906360..3906494 - 135 WP_033179080.1 hypothetical protein -
P7I87_RS18515 (P7I87_18515) 3906504..3908480 - 1977 WP_023125171.1 DEAD/DEAH box helicase -
P7I87_RS18520 (P7I87_18520) 3908477..3910372 - 1896 WP_031640357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaIMP-18 / ant(3'')-Ia / sul1 - 3796954..4178213 381259


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280906 WP_003120987.1 NZ_CP124632:3905362-3905661 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280906 WP_003448662.1 NZ_CP124632:3905658-3905948 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References