Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2033029..2034724 Replicon chromosome
Accession NZ_CP124632
Organism Pseudomonas aeruginosa strain 2021CK-01162

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I87_RS09540 Protein ID WP_023095293.1
Coordinates 2033029..2033898 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I87_RS09545 Protein ID WP_003112902.1
Coordinates 2033891..2034724 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I87_RS09515 (P7I87_09515) 2029037..2029888 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
P7I87_RS09520 (P7I87_09520) 2029929..2030936 + 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I87_RS09525 (P7I87_09525) 2030933..2031709 + 777 WP_003112898.1 ABC transporter permease -
P7I87_RS09530 (P7I87_09530) 2031715..2032476 + 762 WP_003112899.1 SDR family oxidoreductase -
P7I87_RS09535 (P7I87_09535) 2032490..2033020 + 531 WP_003112900.1 cupin domain-containing protein -
P7I87_RS09540 (P7I87_09540) 2033029..2033898 + 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I87_RS09545 (P7I87_09545) 2033891..2034724 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I87_RS09550 (P7I87_09550) 2034711..2035508 + 798 WP_022579702.1 SDR family oxidoreductase -
P7I87_RS09555 (P7I87_09555) 2035501..2037182 + 1682 Protein_1890 thiamine pyrophosphate-binding protein -
P7I87_RS09560 (P7I87_09560) 2037193..2037996 + 804 WP_003112905.1 aspartate dehydrogenase -
P7I87_RS09565 (P7I87_09565) 2038008..2039491 + 1484 Protein_1892 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280903 WP_023095293.1 NZ_CP124632:2033029-2033898 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280903 WP_003112902.1 NZ_CP124632:2033891-2034724 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References