280901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6507525..6509220 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P7I86_RS31105 Protein ID WP_023095293.1
Coordinates 6508351..6509220 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag P7I86_RS31100 Protein ID WP_003112902.1
Coordinates 6507525..6508358 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS31080 (P7I86_31080) 6502756..6504240 - 1485 WP_022579701.1 aldehyde dehydrogenase -
P7I86_RS31085 (P7I86_31085) 6504252..6505055 - 804 WP_003112905.1 aspartate dehydrogenase -
P7I86_RS31090 (P7I86_31090) 6505066..6506748 - 1683 Protein_6134 thiamine pyrophosphate-binding protein -
P7I86_RS31095 (P7I86_31095) 6506741..6507538 - 798 WP_022579702.1 SDR family oxidoreductase -
P7I86_RS31100 (P7I86_31100) 6507525..6508358 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
P7I86_RS31105 (P7I86_31105) 6508351..6509220 - 870 WP_023095293.1 alpha/beta hydrolase Toxin
P7I86_RS31110 (P7I86_31110) 6509229..6509759 - 531 WP_003112900.1 cupin domain-containing protein -
P7I86_RS31115 (P7I86_31115) 6509773..6510534 - 762 WP_003112899.1 SDR family oxidoreductase -
P7I86_RS31120 (P7I86_31120) 6510540..6511316 - 777 WP_003112898.1 ABC transporter permease -
P7I86_RS31125 (P7I86_31125) 6511313..6512320 - 1008 WP_022579704.1 ABC transporter substrate-binding protein -
P7I86_RS31130 (P7I86_31130) 6512361..6513212 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30379.61 Da        Isoelectric Point: 6.8139

>T280901 WP_023095293.1 NZ_CP124626:c6509220-6508351 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPISGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT280901 WP_003112902.1 NZ_CP124626:c6508358-6507525 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References