280900

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 6200216..6201724 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I86_RS29555 Protein ID WP_003119682.1
Coordinates 6201137..6201724 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag P7I86_RS29550 Protein ID WP_003117606.1
Coordinates 6200216..6201070 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS29535 (P7I86_29535) 6195635..6195844 + 210 WP_003091604.1 cold-shock protein -
P7I86_RS29540 (P7I86_29540) 6195905..6197779 - 1875 WP_003117607.1 MFS transporter -
P7I86_RS29545 (P7I86_29545) 6197954..6200119 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
P7I86_RS29550 (P7I86_29550) 6200216..6201070 - 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
P7I86_RS29555 (P7I86_29555) 6201137..6201724 - 588 WP_003119682.1 GNAT family protein Toxin
P7I86_RS29560 (P7I86_29560) 6201990..6205469 + 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280900 WP_003119682.1 NZ_CP124626:c6201724-6201137 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT280900 WP_003117606.1 NZ_CP124626:c6201070-6200216 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References