28090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2225421..2226109 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag RVBD_RS10405 Protein ID WP_003409958.1
Coordinates 2225421..2225840 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag RVBD_RS10410 Protein ID WP_003409968.1
Coordinates 2225849..2226109 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS10385 2220916..2221764 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
RVBD_RS10390 2221727..2223172 - 1446 WP_003899115.1 APC family permease -
RVBD_RS10395 2223351..2224037 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
RVBD_RS10400 2224228..2225196 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
RVBD_RS10405 2225421..2225840 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS10410 2225849..2226109 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RVBD_RS10415 2226252..2227928 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
RVBD_RS10420 2227916..2228569 - 654 WP_003409976.1 cutinase Cfp21 -
RVBD_RS10425 2228684..2228914 + 231 WP_003409980.1 DUF167 domain-containing protein -
RVBD_RS10430 2228999..2229910 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
RVBD_RS10435 2230019..2230618 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T28090 WP_003409958.1 NC_018143:c2225840-2225421 [Mycobacterium tuberculosis H37Rv]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T28090 NC_018143:c2225840-2225421 [Mycobacterium tuberculosis H37Rv]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT28090 WP_003409968.1 NC_018143:c2226109-2225849 [Mycobacterium tuberculosis H37Rv]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT28090 NC_018143:c2226109-2225849 [Mycobacterium tuberculosis H37Rv]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References