Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 4254175..4255395 | Replicon | chromosome |
| Accession | NZ_CP124626 | ||
| Organism | Pseudomonas aeruginosa strain 2021CK-01161 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | P7I86_RS20495 | Protein ID | WP_282393719.1 |
| Coordinates | 4254175..4254753 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | P7I86_RS20500 | Protein ID | WP_003088112.1 |
| Coordinates | 4254841..4255395 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I86_RS20480 (P7I86_20480) | 4249451..4250727 | + | 1277 | Protein_4034 | TolC family protein | - |
| P7I86_RS20485 (P7I86_20485) | 4250717..4252888 | + | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| P7I86_RS20490 (P7I86_20490) | 4252878..4254065 | + | 1188 | WP_003088106.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| P7I86_RS20495 (P7I86_20495) | 4254175..4254753 | - | 579 | WP_282393719.1 | HD domain-containing protein | Toxin |
| P7I86_RS20500 (P7I86_20500) | 4254841..4255395 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| P7I86_RS20505 (P7I86_20505) | 4255553..4257748 | - | 2196 | WP_023095788.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| P7I86_RS20510 (P7I86_20510) | 4257753..4258214 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| P7I86_RS20515 (P7I86_20515) | 4258545..4258868 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| P7I86_RS20520 (P7I86_20520) | 4258881..4259279 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| P7I86_RS20525 (P7I86_20525) | 4259276..4259827 | - | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21912.77 Da Isoelectric Point: 5.6184
>T280898 WP_282393719.1 NZ_CP124626:c4254753-4254175 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLNLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLNLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280898 WP_003088112.1 NZ_CP124626:c4255395-4254841 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|