Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3212495..3213753 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag P7I86_RS15345 Protein ID WP_003086331.1
Coordinates 3212998..3213753 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I86_RS15340 Protein ID WP_003086329.1
Coordinates 3212495..3212863 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS15320 (P7I86_15320) 3208780..3208935 + 156 WP_003086320.1 zinc ribbon domain-containing protein -
P7I86_RS15325 (P7I86_15325) 3208938..3209413 - 476 Protein_3013 transcription elongation factor GreAB -
P7I86_RS15330 (P7I86_15330) 3209588..3211080 + 1493 Protein_3014 aldehyde dehydrogenase family protein -
P7I86_RS15335 (P7I86_15335) 3211136..3212422 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
P7I86_RS15340 (P7I86_15340) 3212495..3212863 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I86_RS15345 (P7I86_15345) 3212998..3213753 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
P7I86_RS15350 (P7I86_15350) 3214522..3215883 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I86_RS15355 (P7I86_15355) 3216038..3218581 - 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T280897 WP_003086331.1 NZ_CP124626:3212998-3213753 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280897 WP_003086329.1 NZ_CP124626:3212495-3212863 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References