Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2420154..2420740 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P7I86_RS11400 Protein ID WP_003120987.1
Coordinates 2420154..2420453 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P7I86_RS11405 Protein ID WP_003448662.1
Coordinates 2420450..2420740 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS11380 (P7I86_11380) 2415268..2415801 - 534 WP_023125174.1 type IV pilus biogenesis protein PilP -
P7I86_RS11385 (P7I86_11385) 2415791..2417116 - 1326 WP_023125173.1 type 4b pilus protein PilO2 -
P7I86_RS11390 (P7I86_11390) 2417120..2418829 - 1710 WP_023125172.1 PilN family type IVB pilus formation outer membrane protein -
P7I86_RS11395 (P7I86_11395) 2418829..2419952 - 1124 Protein_2242 TcpQ domain-containing protein -
P7I86_RS11400 (P7I86_11400) 2420154..2420453 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I86_RS11405 (P7I86_11405) 2420450..2420740 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P7I86_RS11410 (P7I86_11410) 2420823..2421155 - 333 WP_031640358.1 hypothetical protein -
P7I86_RS11415 (P7I86_11415) 2421152..2421286 - 135 WP_033179080.1 hypothetical protein -
P7I86_RS11420 (P7I86_11420) 2421296..2423272 - 1977 WP_023125171.1 DEAD/DEAH box helicase -
P7I86_RS11425 (P7I86_11425) 2423269..2425164 - 1896 WP_031640357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2365769..2448265 82496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280895 WP_003120987.1 NZ_CP124626:2420154-2420453 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280895 WP_003448662.1 NZ_CP124626:2420450-2420740 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References