280893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 799198..799703 Replicon chromosome
Accession NZ_CP124626
Organism Pseudomonas aeruginosa strain 2021CK-01161

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I86_RS03710 Protein ID WP_003083773.1
Coordinates 799422..799703 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I86_RS03705 Protein ID WP_003083775.1
Coordinates 799198..799425 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I86_RS03680 (P7I86_03680) 794215..795708 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
P7I86_RS03685 (P7I86_03685) 795876..797303 + 1428 WP_003083784.1 GABA permease -
P7I86_RS03690 (P7I86_03690) 797387..797728 - 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
P7I86_RS03695 (P7I86_03695) 797801..798301 - 501 WP_003083778.1 LEA type 2 family protein -
P7I86_RS03700 (P7I86_03700) 798402..799022 + 621 WP_003101226.1 hypothetical protein -
P7I86_RS03705 (P7I86_03705) 799198..799425 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I86_RS03710 (P7I86_03710) 799422..799703 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I86_RS03715 (P7I86_03715) 800003..800911 + 909 WP_003083769.1 LysR family transcriptional regulator -
P7I86_RS03720 (P7I86_03720) 800943..801353 - 411 WP_003110659.1 aegerolysin family protein -
P7I86_RS03725 (P7I86_03725) 801533..802267 - 735 WP_003083764.1 GntR family transcriptional regulator -
P7I86_RS03730 (P7I86_03730) 802368..803054 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I86_RS03735 (P7I86_03735) 803103..804452 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaGES-19 / blaGES-20 / blaOXA-2 / sul1 / tet(G) / floR cheW / vgrG1b / vgrG1a / clpV1 / hsiH1 / hsiG1 / hsiF1 / hsiE1 / hcp1 / hsiC1/vipB / hsiB1/vipA / hsiA1 / fha1 / lip1 / hsiJ1 / dotU1 / icmF1/tssM1 / tagF/pppB / pppA / ppkA / tagT / tagS / tagR / tagQ / phzH / exoT 734753..1093141 358388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280893 WP_003083773.1 NZ_CP124626:799422-799703 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280893 WP_003083775.1 NZ_CP124626:799198-799425 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References