Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 6054164..6054748 Replicon chromosome
Accession NZ_CP124624
Organism Pseudomonas aeruginosa strain 2021CK-01157

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P7I83_RS28200 Protein ID WP_033996895.1
Coordinates 6054458..6054748 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P7I83_RS28195 Protein ID WP_033996897.1
Coordinates 6054164..6054457 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I83_RS28165 (P7I83_28165) 6049514..6049747 + 234 WP_033996905.1 hypothetical protein -
P7I83_RS28170 (P7I83_28170) 6049767..6052484 + 2718 WP_033996995.1 toprim domain-containing protein -
P7I83_RS28175 (P7I83_28175) 6052529..6052672 + 144 WP_153576040.1 hypothetical protein -
P7I83_RS28180 (P7I83_28180) 6052723..6053298 + 576 WP_052157654.1 hypothetical protein -
P7I83_RS28185 (P7I83_28185) 6053490..6053660 + 171 WP_108242490.1 antitoxin -
P7I83_RS28190 (P7I83_28190) 6053657..6054049 + 393 WP_033996900.1 hypothetical protein -
P7I83_RS28195 (P7I83_28195) 6054164..6054457 - 294 WP_033996897.1 putative addiction module antidote protein Antitoxin
P7I83_RS28200 (P7I83_28200) 6054458..6054748 - 291 WP_033996895.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I83_RS28205 (P7I83_28205) 6055059..6055259 + 201 WP_033996893.1 hypothetical protein -
P7I83_RS28210 (P7I83_28210) 6055259..6055483 + 225 WP_033996891.1 hypothetical protein -
P7I83_RS28215 (P7I83_28215) 6055492..6056034 + 543 WP_161566247.1 phage antirepressor N-terminal domain-containing protein -
P7I83_RS28220 (P7I83_28220) 6056054..6056251 + 198 WP_033996889.1 hypothetical protein -
P7I83_RS28225 (P7I83_28225) 6056330..6056539 + 210 WP_033996886.1 hypothetical protein -
P7I83_RS28230 (P7I83_28230) 6056536..6057678 + 1143 WP_033996883.1 integrase -
P7I83_RS28235 (P7I83_28235) 6058077..6059135 + 1059 WP_003096179.1 dTDP-glucose 4,6-dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 6020756..6059135 38379
- inside Prophage - - 6018125..6059135 41010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11001.67 Da        Isoelectric Point: 6.3329

>T280892 WP_033996895.1 NZ_CP124624:c6054748-6054458 [Pseudomonas aeruginosa]
MYSIIETEAFSDWLNGLKDTVTRMRLIKRLQRASLGNLGDVKPVGEGVYEMREFFGPGWRMYYVQQGDVLLIMLGGGDKS
SQQRDIERAIQLSKEL

Download         Length: 291 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10648.27 Da        Isoelectric Point: 6.4678

>AT280892 WP_033996897.1 NZ_CP124624:c6054457-6054164 [Pseudomonas aeruginosa]
MNKTKLNMRPFDAAHYLNNEEEMAAYLDVILEDNDPALLAVALGDIARARGMTELARKTGLSRESLYKSLSGERVPSTET
LLKVIHALGFKLTVSAA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References