Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147840..148345 Replicon chromosome
Accession NZ_CP124624
Organism Pseudomonas aeruginosa strain 2021CK-01157

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P7I83_RS00655 Protein ID WP_003083773.1
Coordinates 147840..148121 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P7I83_RS00660 Protein ID WP_003083775.1
Coordinates 148118..148345 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I83_RS00630 (P7I83_00630) 143091..144440 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
P7I83_RS00635 (P7I83_00635) 144489..145175 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P7I83_RS00640 (P7I83_00640) 145276..146010 + 735 WP_003110658.1 GntR family transcriptional regulator -
P7I83_RS00645 (P7I83_00645) 146190..146600 + 411 WP_003110659.1 aegerolysin family protein -
P7I83_RS00650 (P7I83_00650) 146632..147540 - 909 WP_003083769.1 LysR family transcriptional regulator -
P7I83_RS00655 (P7I83_00655) 147840..148121 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P7I83_RS00660 (P7I83_00660) 148118..148345 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P7I83_RS00665 (P7I83_00665) 148521..149141 - 621 WP_003101226.1 hypothetical protein -
P7I83_RS00670 (P7I83_00670) 149242..149742 + 501 WP_003162763.1 LEA type 2 family protein -
P7I83_RS00675 (P7I83_00675) 149815..150156 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
P7I83_RS00680 (P7I83_00680) 150238..151665 - 1428 WP_003083784.1 GABA permease -
P7I83_RS00685 (P7I83_00685) 151834..153327 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T280886 WP_003083773.1 NZ_CP124624:c148121-147840 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT280886 WP_003083775.1 NZ_CP124624:c148345-148118 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References