280884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4982057..4982665 Replicon chromosome
Accession NZ_CP124622
Organism Pseudomonas aeruginosa strain 2021CK-01159

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag P7I85_RS23290 Protein ID WP_003114156.1
Coordinates 4982057..4982404 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A643EG04
Locus tag P7I85_RS23295 Protein ID WP_042857565.1
Coordinates 4982414..4982665 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I85_RS23260 (P7I85_23260) 4977477..4977689 + 213 WP_275988278.1 cysteine-rich CWC family protein -
P7I85_RS23265 (P7I85_23265) 4977689..4978381 + 693 WP_023104853.1 16S rRNA pseudouridine(516) synthase -
P7I85_RS23270 (P7I85_23270) 4978517..4979560 + 1044 WP_003098363.1 L,D-transpeptidase -
P7I85_RS23275 (P7I85_23275) 4979640..4980377 + 738 WP_172773749.1 murein L,D-transpeptidase catalytic domain family protein -
P7I85_RS23280 (P7I85_23280) 4980829..4981731 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
P7I85_RS23290 (P7I85_23290) 4982057..4982404 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P7I85_RS23295 (P7I85_23295) 4982414..4982665 - 252 WP_042857565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P7I85_RS23300 (P7I85_23300) 4982879..4983862 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
P7I85_RS23305 (P7I85_23305) 4983862..4985154 - 1293 WP_003454977.1 hypothetical protein -
P7I85_RS23310 (P7I85_23310) 4985413..4986675 - 1263 WP_282414015.1 zonular occludens toxin domain-containing protein -
P7I85_RS23315 (P7I85_23315) 4986677..4987027 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4982057..5002582 20525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T280884 WP_003114156.1 NZ_CP124622:c4982404-4982057 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9456.81 Da        Isoelectric Point: 9.4808

>AT280884 WP_042857565.1 NZ_CP124622:c4982665-4982414 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGIPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A643EG04

References