Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4707110..4708618 Replicon chromosome
Accession NZ_CP124622
Organism Pseudomonas aeruginosa strain 2021CK-01159

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag P7I85_RS21975 Protein ID WP_003119682.1
Coordinates 4708031..4708618 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag P7I85_RS21970 Protein ID WP_003119683.1
Coordinates 4707110..4707964 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I85_RS21955 (P7I85_21955) 4702529..4702738 + 210 WP_003091604.1 cold-shock protein -
P7I85_RS21960 (P7I85_21960) 4702799..4704673 - 1875 WP_003091605.1 MFS transporter -
P7I85_RS21965 (P7I85_21965) 4704848..4707013 - 2166 WP_003115567.1 TonB-dependent receptor family protein -
P7I85_RS21970 (P7I85_21970) 4707110..4707964 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
P7I85_RS21975 (P7I85_21975) 4708031..4708618 - 588 WP_003119682.1 GNAT family protein Toxin
P7I85_RS21980 (P7I85_21980) 4708885..4712364 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280883 WP_003119682.1 NZ_CP124622:c4708618-4708031 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT280883 WP_003119683.1 NZ_CP124622:c4707964-4707110 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References