Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2903439..2904660 | Replicon | chromosome |
| Accession | NZ_CP124622 | ||
| Organism | Pseudomonas aeruginosa strain 2021CK-01159 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | P7I85_RS13635 | Protein ID | WP_003114949.1 |
| Coordinates | 2903439..2904017 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | P7I85_RS13640 | Protein ID | WP_003088112.1 |
| Coordinates | 2904106..2904660 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P7I85_RS13620 (P7I85_13620) | 2898716..2899993 | + | 1278 | WP_003102743.1 | TolC family protein | - |
| P7I85_RS13625 (P7I85_13625) | 2899983..2902154 | + | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| P7I85_RS13630 (P7I85_13630) | 2902144..2903331 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| P7I85_RS13635 (P7I85_13635) | 2903439..2904017 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| P7I85_RS13640 (P7I85_13640) | 2904106..2904660 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| P7I85_RS13645 (P7I85_13645) | 2904818..2907013 | - | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| P7I85_RS13650 (P7I85_13650) | 2907018..2907479 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| P7I85_RS13655 (P7I85_13655) | 2907810..2908133 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| P7I85_RS13660 (P7I85_13660) | 2908146..2908544 | + | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
| P7I85_RS13665 (P7I85_13665) | 2908541..2909092 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T280882 WP_003114949.1 NZ_CP124622:c2904017-2903439 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280882 WP_003088112.1 NZ_CP124622:c2904660-2904106 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|