Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1949780..1951038 Replicon chromosome
Accession NZ_CP124622
Organism Pseudomonas aeruginosa strain 2021CK-01159

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag P7I85_RS09145 Protein ID WP_003163133.1
Coordinates 1950283..1951038 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P7I85_RS09140 Protein ID WP_003086329.1
Coordinates 1949780..1950148 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P7I85_RS09120 (P7I85_09120) 1945943..1946218 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
P7I85_RS09125 (P7I85_09125) 1946221..1946697 - 477 WP_003112531.1 hypothetical protein -
P7I85_RS09130 (P7I85_09130) 1946872..1948365 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P7I85_RS09135 (P7I85_09135) 1948421..1949707 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
P7I85_RS09140 (P7I85_09140) 1949780..1950148 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P7I85_RS09145 (P7I85_09145) 1950283..1951038 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
P7I85_RS09150 (P7I85_09150) 1951806..1953167 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P7I85_RS09155 (P7I85_09155) 1953322..1955865 - 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T280881 WP_003163133.1 NZ_CP124622:1950283-1951038 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280881 WP_003086329.1 NZ_CP124622:1949780-1950148 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References