Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 730379..731928 Replicon chromosome
Accession NZ_CP124614
Organism Vibrio sp. YMD68

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QF117_RS09475 Protein ID WP_282388678.1
Coordinates 730379..731680 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QF117_RS09480 Protein ID WP_282388679.1
Coordinates 731680..731928 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QF117_RS09460 (QF117_09460) 725921..726463 - 543 WP_282388675.1 hypothetical protein -
QF117_RS09465 (QF117_09465) 727000..728343 + 1344 WP_282388676.1 GTPase HflX -
QF117_RS09470 (QF117_09470) 728571..729890 - 1320 WP_282388677.1 MBL fold metallo-hydrolase -
QF117_RS09475 (QF117_09475) 730379..731680 - 1302 WP_282388678.1 type II toxin-antitoxin system HipA family toxin Toxin
QF117_RS09480 (QF117_09480) 731680..731928 - 249 WP_282388679.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QF117_RS09485 (QF117_09485) 733062..733391 + 330 WP_282388680.1 helix-turn-helix transcriptional regulator -
QF117_RS09490 (QF117_09490) 733388..734647 + 1260 WP_282388681.1 type II toxin-antitoxin system HipA family toxin -
QF117_RS09500 (QF117_09500) 735479..735961 - 483 WP_017034182.1 SsrA-binding protein SmpB -
QF117_RS09505 (QF117_09505) 736077..736520 + 444 WP_282388682.1 SRPBCC family protein -
QF117_RS09510 (QF117_09510) 736510..736818 + 309 WP_026026567.1 RnfH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48733.08 Da        Isoelectric Point: 6.9502

>T280877 WP_282388678.1 NZ_CP124614:c731680-730379 [Vibrio sp. YMD68]
MQKLNAYMNGELVGTLNKQKNGAHTFQYDKTWVTSDKSRPLSLSLKLQLPPIASDSVINYFDNLLPDSPKVRDRIVARCK
ASSKQPFDLLKEVGKDCVGAIALISPEQPYKNEPLNYQVLDDIKLDAVLSAYKSDIPLGMVEEEEDFRISVAGAQEKTAL
LSVDEQWCIPKGNTPTTHSIKLPIGEIQQANTTLDLQDSVENEYLCIELAKALGFAVPNVHMIKNDNQKALAVERFDRRW
TKDKANLLRLPQEDMCQVFGMPSSIKYESQGGPGISEIMKLLMGSSNALEDQYNFMKFQVFQWIIGATDGHAKNYSIYIE
KGGSYRLTPFYDILSAYPLLGGRGLNIRKLKLAMGLKATRGKKYEINKILPRHFLDTAKAVNFSQDKMQEILNELKDEFP
EAILQVKAKLPEDFPEKISDSIFENATKLLSKI

Download         Length: 1302 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9412.69 Da        Isoelectric Point: 4.9816

>AT280877 WP_282388679.1 NZ_CP124614:c731928-731680 [Vibrio sp. YMD68]
MIYSPKQLADMMLLIRQKNGWTQSELSKRVGIKQATISNFENSPDKTTLSTFFKLIQAMELTLSIQEKAQVSSQDSQDDE
NW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References