Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1356979..1357895 Replicon chromosome
Accession NZ_CP124601
Organism Bacillus stercoris strain BS21

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag QI003_RS06930 Protein ID WP_095431469.1
Coordinates 1357149..1357895 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4NV07
Locus tag QI003_RS06925 Protein ID WP_003239095.1
Coordinates 1356979..1357149 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QI003_RS06890 (QI003_06890) 1353840..1354169 + 330 WP_071580569.1 XkdW family protein -
QI003_RS06895 (QI003_06895) 1354166..1354330 + 165 WP_282374235.1 XkdX family protein -
QI003_RS06900 (QI003_06900) 1354375..1355214 + 840 WP_282374236.1 phage portal protein -
QI003_RS06905 (QI003_06905) 1355267..1355536 + 270 WP_003232655.1 hemolysin XhlA family protein -
QI003_RS06910 (QI003_06910) 1355549..1355812 + 264 WP_003232653.1 phage holin -
QI003_RS06915 (QI003_06915) 1355825..1356718 + 894 WP_282374237.1 N-acetylmuramoyl-L-alanine amidase -
QI003_RS06920 (QI003_06920) 1356756..1356893 - 138 WP_136654612.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QI003_RS06925 (QI003_06925) 1356979..1357149 - 171 WP_003239095.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QI003_RS06930 (QI003_06930) 1357149..1357895 - 747 WP_095431469.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QI003_RS06935 (QI003_06935) 1358005..1359006 - 1002 WP_014663667.1 inorganic phosphate transporter -
QI003_RS06940 (QI003_06940) 1359019..1359636 - 618 WP_003218470.1 DUF47 domain-containing protein -
QI003_RS06945 (QI003_06945) 1359913..1361229 - 1317 WP_014663668.1 serine/threonine exchanger -
QI003_RS06950 (QI003_06950) 1361618..1362568 + 951 WP_282374238.1 ring-cleaving dioxygenase -
QI003_RS06955 (QI003_06955) 1362653..1362798 + 146 Protein_1306 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1321708..1366308 44600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29070.57 Da        Isoelectric Point: 4.6145

>T280870 WP_095431469.1 NZ_CP124601:c1357895-1357149 [Bacillus stercoris]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWDRYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CQYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKMVLIPFTIETKNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6555.59 Da        Isoelectric Point: 10.8401

>AT280870 WP_003239095.1 NZ_CP124601:c1357149-1356979 [Bacillus stercoris]
MERAFQNGCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G4NV07

References