280867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5621931..5622517 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag QIU11_RS26675 Protein ID WP_003120987.1
Coordinates 5622218..5622517 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag QIU11_RS26670 Protein ID WP_003448662.1
Coordinates 5621931..5622221 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS26650 (QIU11_26650) 5617082..5617291 + 210 WP_003105733.1 cold-shock protein -
QIU11_RS26655 (QIU11_26655) 5617513..5619402 + 1890 WP_016851610.1 hypothetical protein -
QIU11_RS26660 (QIU11_26660) 5619399..5621375 + 1977 WP_058177552.1 DEAD/DEAH box helicase -
QIU11_RS26665 (QIU11_26665) 5621516..5621860 + 345 WP_016851612.1 hypothetical protein -
QIU11_RS26670 (QIU11_26670) 5621931..5622221 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
QIU11_RS26675 (QIU11_26675) 5622218..5622517 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QIU11_RS26680 (QIU11_26680) 5622719..5623843 + 1125 WP_058177553.1 TcpQ domain-containing protein -
QIU11_RS26685 (QIU11_26685) 5623843..5625552 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
QIU11_RS26690 (QIU11_26690) 5625556..5626881 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
QIU11_RS26695 (QIU11_26695) 5626871..5627404 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5595464..5691034 95570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T280867 WP_003120987.1 NZ_CP124600:c5622517-5622218 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT280867 WP_003448662.1 NZ_CP124600:c5622221-5621931 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References