Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147471..147976 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag QIU11_RS00675 Protein ID WP_003121619.1
Coordinates 147471..147752 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag QIU11_RS00680 Protein ID WP_003112628.1
Coordinates 147749..147976 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS00650 (QIU11_00650) 142722..144071 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
QIU11_RS00655 (QIU11_00655) 144120..144806 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QIU11_RS00660 (QIU11_00660) 144907..145641 + 735 WP_033867727.1 GntR family transcriptional regulator -
QIU11_RS00665 (QIU11_00665) 145821..146231 + 411 WP_003110659.1 aegerolysin family protein -
QIU11_RS00670 (QIU11_00670) 146263..147171 - 909 WP_016561475.1 LysR family transcriptional regulator -
QIU11_RS00675 (QIU11_00675) 147471..147752 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
QIU11_RS00680 (QIU11_00680) 147749..147976 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
QIU11_RS00685 (QIU11_00685) 148152..148772 - 621 WP_003101226.1 hypothetical protein -
QIU11_RS00690 (QIU11_00690) 148873..149373 + 501 WP_003112629.1 LEA type 2 family protein -
QIU11_RS00695 (QIU11_00695) 149446..149787 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QIU11_RS00700 (QIU11_00700) 149869..151296 - 1428 WP_023083858.1 GABA permease -
QIU11_RS00705 (QIU11_00705) 151465..152958 - 1494 WP_023115963.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T280861 WP_003121619.1 NZ_CP124600:c147752-147471 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT280861 WP_003112628.1 NZ_CP124600:c147976-147749 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References