Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rlegTA/AbiEii-AbiEi |
| Location | 3072561..3074080 | Replicon | chromosome |
| Accession | NZ_CP124576 | ||
| Organism | Sphingobium sp. AP49 | ||
Toxin (Protein)
| Gene name | rlegT | Uniprot ID | J2D6Y5 |
| Locus tag | PMI04_RS14655 | Protein ID | WP_007706637.1 |
| Coordinates | 3073166..3074080 (+) | Length | 305 a.a. |
Antitoxin (Protein)
| Gene name | rlegA | Uniprot ID | J2WTH1 |
| Locus tag | PMI04_RS14650 | Protein ID | WP_007706639.1 |
| Coordinates | 3072561..3073169 (+) | Length | 203 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PMI04_RS14635 (PMI04_014635) | 3067859..3068704 | - | 846 | WP_007713724.1 | DUF932 domain-containing protein | - |
| PMI04_RS14640 (PMI04_014640) | 3068998..3069297 | - | 300 | WP_007713727.1 | DUF736 domain-containing protein | - |
| PMI04_RS14645 (PMI04_014645) | 3069954..3071981 | - | 2028 | WP_007713729.1 | ParB/RepB/Spo0J family partition protein | - |
| PMI04_RS14650 (PMI04_014650) | 3072561..3073169 | + | 609 | WP_007706639.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| PMI04_RS14655 (PMI04_014655) | 3073166..3074080 | + | 915 | WP_007706637.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PMI04_RS14660 (PMI04_014660) | 3074194..3074976 | + | 783 | WP_007706625.1 | phage Gp37/Gp68 family protein | - |
| PMI04_RS14665 (PMI04_014665) | 3075010..3076263 | + | 1254 | WP_007706622.1 | three-Cys-motif partner protein TcmP | - |
| PMI04_RS14670 (PMI04_014670) | 3076551..3077417 | - | 867 | WP_007706619.1 | HNH endonuclease signature motif containing protein | - |
| PMI04_RS14675 (PMI04_014675) | 3077417..3078313 | - | 897 | WP_007706602.1 | abortive infection family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3058950..3098592 | 39642 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 305 a.a. Molecular weight: 33312.31 Da Isoelectric Point: 5.2357
>T280859 WP_007706637.1 NZ_CP124576:3073166-3074080 [Sphingobium sp. AP49]
MSRPPKNMAISVRDRLTARARERRENAQLLMTRYVIERLLFRLSLSPHRERFVLKGAMLFSLWAAAPYRATGDLDLLGIG
ENAPEQLAAVFQEILAVAVDDDGIVFRPETLRAAAARAEDEYAGVRIDFVAELAGARLPMHVDIGYGDAITPGAIEIEYP
SLLGQPTAHLRAYPPETVVAEKFQAMVALGMLNTRLKDFYDIWAIAGSFAFDGAVLSRAIQATFDRRQTPLPGETPPALT
PAFADEKQAEWTAFLRRTEIALAPEPFAAIQAQVATLVMPPVLALGQGAAFAGDWPSGGPWKER
MSRPPKNMAISVRDRLTARARERRENAQLLMTRYVIERLLFRLSLSPHRERFVLKGAMLFSLWAAAPYRATGDLDLLGIG
ENAPEQLAAVFQEILAVAVDDDGIVFRPETLRAAAARAEDEYAGVRIDFVAELAGARLPMHVDIGYGDAITPGAIEIEYP
SLLGQPTAHLRAYPPETVVAEKFQAMVALGMLNTRLKDFYDIWAIAGSFAFDGAVLSRAIQATFDRRQTPLPGETPPALT
PAFADEKQAEWTAFLRRTEIALAPEPFAAIQAQVATLVMPPVLALGQGAAFAGDWPSGGPWKER
Download Length: 915 bp
Antitoxin
Download Length: 203 a.a. Molecular weight: 22368.79 Da Isoelectric Point: 9.5151
>AT280859 WP_007706639.1 NZ_CP124576:3072561-3073169 [Sphingobium sp. AP49]
MEPTTHRERALEVVRHRGIARGRDFDAAGVTRATLQRLRDEGVLQQVGRGLYKLADANVDSSTSLAEAVRIQPRGVICLL
SALQFHELTTQTPHAVWMMLGQKDWAPVNPSVALKIVRASGEALTAGVETHVIDGVPVPITVPAKTVADCFKHRNKIGID
VAVEALRDFMKSRPRPDLNAIYRYAELDRVQSVIRPYLEAMT
MEPTTHRERALEVVRHRGIARGRDFDAAGVTRATLQRLRDEGVLQQVGRGLYKLADANVDSSTSLAEAVRIQPRGVICLL
SALQFHELTTQTPHAVWMMLGQKDWAPVNPSVALKIVRASGEALTAGVETHVIDGVPVPITVPAKTVADCFKHRNKIGID
VAVEALRDFMKSRPRPDLNAIYRYAELDRVQSVIRPYLEAMT
Download Length: 609 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|