Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2898584..2899191 Replicon chromosome
Accession NZ_CP124576
Organism Sphingobium sp. AP49

Toxin (Protein)


Gene name relE Uniprot ID J2LDW5
Locus tag PMI04_RS13795 Protein ID WP_007706215.1
Coordinates 2898584..2898889 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J2WTW9
Locus tag PMI04_RS13800 Protein ID WP_007706214.1
Coordinates 2898886..2899191 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMI04_RS13770 (PMI04_013770) 2893616..2894230 - 615 WP_007706227.1 hypothetical protein -
PMI04_RS13775 (PMI04_013775) 2894386..2894643 + 258 WP_007706222.1 hypothetical protein -
PMI04_RS13780 (PMI04_013780) 2895059..2896159 + 1101 WP_007706220.1 DUF262 domain-containing protein -
PMI04_RS13785 (PMI04_013785) 2896156..2897277 + 1122 WP_007706217.1 DUF3696 domain-containing protein -
PMI04_RS13790 (PMI04_013790) 2897323..2898189 + 867 WP_157178078.1 hypothetical protein -
PMI04_RS13795 (PMI04_013795) 2898584..2898889 - 306 WP_007706215.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
PMI04_RS13800 (PMI04_013800) 2898886..2899191 - 306 WP_007706214.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PMI04_RS13805 (PMI04_013805) 2899740..2899955 + 216 WP_081490990.1 AlpA family phage regulatory protein -
PMI04_RS13810 (PMI04_013810) 2899952..2900146 + 195 WP_007706212.1 helix-turn-helix domain-containing protein -
PMI04_RS13815 (PMI04_013815) 2900121..2901335 - 1215 WP_037485537.1 site-specific integrase -
PMI04_RS13820 (PMI04_013820) 2901843..2902673 + 831 WP_007706204.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2880635..2901553 20918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-59)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11442.99 Da        Isoelectric Point: 5.6211

>T280858 WP_007706215.1 NZ_CP124576:c2898889-2898584 [Sphingobium sp. AP49]
MKLAWSNRATTDRLAIFIWIAEDNPQAAADVDDRIEAAAQRLKDFPNSGRPGRIEGTRELVIAHTPYIAPYQIIGDTVRV
LRVIHGARMWPHDVPPEFEPE

Download         Length: 306 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11413.92 Da        Isoelectric Point: 5.2053

>AT280858 WP_007706214.1 NZ_CP124576:c2899191-2898886 [Sphingobium sp. AP49]
MANNALIQTRIDSDVKDRASAVFERMGLTVSDAVRILLTRTAREGVAPMELLVERQAYDQWFRARVQEALDDDRPDINDA
EVSARFAELRANARKGIKPVQ

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2LDW5

Antitoxin

Source ID Structure
AlphaFold DB J2WTW9

References