28085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1947037..1947650 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag RVBD_RS09075 Protein ID WP_003408465.1
Coordinates 1947037..1947426 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag RVBD_RS09080 Protein ID WP_003408469.1
Coordinates 1947423..1947650 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS09040 1942666..1943580 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
RVBD_RS09045 1943583..1944413 + 831 WP_003916848.1 cyclase family protein -
RVBD_RS09050 1944413..1944763 + 351 WP_003898986.1 cupin domain-containing protein -
RVBD_RS09055 1944816..1945634 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
RVBD_RS09060 1945648..1946427 + 780 WP_003408460.1 IclR family transcriptional regulator -
RVBD_RS09075 1947037..1947426 - 390 WP_003408465.1 PIN domain-containing protein Toxin
RVBD_RS09080 1947423..1947650 - 228 WP_003408469.1 antitoxin Antitoxin
RVBD_RS09085 1947868..1949352 + 1485 WP_003408473.1 carboxylase -
RVBD_RS09090 1949349..1950596 + 1248 WP_003408476.1 serine hydrolase -
RVBD_RS09095 1950639..1951058 - 420 WP_003408483.1 hypothetical protein -
RVBD_RS09100 1951048..1951758 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T28085 WP_003408465.1 NC_018143:c1947426-1947037 [Mycobacterium tuberculosis H37Rv]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T28085 NC_018143:c1947426-1947037 [Mycobacterium tuberculosis H37Rv]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT28085 WP_003408469.1 NC_018143:c1947650-1947423 [Mycobacterium tuberculosis H37Rv]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT28085 NC_018143:c1947650-1947423 [Mycobacterium tuberculosis H37Rv]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References