Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1234210..1234988 Replicon chromosome
Accession NZ_CP124534
Organism Xanthomonas campestris strain DX

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag QJS70_RS05235 Protein ID WP_011038220.1
Coordinates 1234210..1234701 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag QJS70_RS05240 Protein ID WP_011038219.1
Coordinates 1234698..1234988 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS70_RS05215 1230461..1231336 + 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -
QJS70_RS05220 1231559..1232032 + 474 WP_012437597.1 hypothetical protein -
QJS70_RS05225 1232063..1232740 + 678 WP_003490678.1 response regulator transcription factor -
QJS70_RS05230 1232733..1234067 + 1335 WP_012437598.1 HAMP domain-containing sensor histidine kinase -
QJS70_RS05235 1234210..1234701 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
QJS70_RS05240 1234698..1234988 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
QJS70_RS05245 1235063..1235464 - 402 WP_019237348.1 SymE family type I addiction module toxin -
QJS70_RS05250 1235996..1236619 - 624 WP_011038217.1 dephospho-CoA kinase -
QJS70_RS05255 1236633..1237496 - 864 WP_011038216.1 A24 family peptidase -
QJS70_RS05260 1237503..1238759 - 1257 WP_011038215.1 type II secretion system F family protein -
QJS70_RS05265 1239086..1239526 + 441 WP_011038214.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1192416..1237796 45380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T280839 WP_011038220.1 NZ_CP124534:c1234701-1234210 [Xanthomonas campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT280839 WP_011038219.1 NZ_CP124534:c1234988-1234698 [Xanthomonas campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References