Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1234220..1234998 Replicon chromosome
Accession NZ_CP124533
Organism Xanthomonas campestris strain JN

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag QJS72_RS05225 Protein ID WP_011038220.1
Coordinates 1234220..1234711 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag QJS72_RS05230 Protein ID WP_011038219.1
Coordinates 1234708..1234998 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS72_RS05205 1230471..1231346 + 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -
QJS72_RS05210 1231569..1232042 + 474 WP_012437597.1 hypothetical protein -
QJS72_RS05215 1232073..1232750 + 678 WP_003490678.1 response regulator transcription factor -
QJS72_RS05220 1232743..1234077 + 1335 WP_012437598.1 HAMP domain-containing sensor histidine kinase -
QJS72_RS05225 1234220..1234711 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
QJS72_RS05230 1234708..1234998 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
QJS72_RS05235 1235073..1235474 - 402 WP_019237348.1 SymE family type I addiction module toxin -
QJS72_RS05240 1236006..1236629 - 624 WP_011038217.1 dephospho-CoA kinase -
QJS72_RS05245 1236643..1237506 - 864 WP_011038216.1 A24 family peptidase -
QJS72_RS05250 1237513..1238769 - 1257 WP_011038215.1 type II secretion system F family protein -
QJS72_RS05255 1239096..1239536 + 441 WP_011038214.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1192426..1237806 45380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T280837 WP_011038220.1 NZ_CP124533:c1234711-1234220 [Xanthomonas campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT280837 WP_011038219.1 NZ_CP124533:c1234998-1234708 [Xanthomonas campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References