280826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4078598..4079114 Replicon chromosome
Accession NZ_CP124522
Organism Salmonella enterica strain PNUSAS118467

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag QJS74_RS19895 Protein ID WP_000220582.1
Coordinates 4078598..4078882 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QJS74_RS19900 Protein ID WP_000212724.1
Coordinates 4078872..4079114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS74_RS19880 (4073809) 4073809..4075461 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
QJS74_RS19885 (4075870) 4075870..4078008 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QJS74_RS19890 (4078130) 4078130..4078594 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJS74_RS19895 (4078598) 4078598..4078882 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJS74_RS19900 (4078872) 4078872..4079114 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJS74_RS19905 (4079192) 4079192..4081105 - 1914 WP_001212142.1 BglG family transcription antiterminator -
QJS74_RS19910 (4081122) 4081122..4081862 - 741 WP_000779259.1 KDGP aldolase family protein -
QJS74_RS19915 (4081859) 4081859..4082977 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QJS74_RS19920 (4082961) 4082961..4084094 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T280826 WP_000220582.1 NZ_CP124522:c4078882-4078598 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT280826 WP_000212724.1 NZ_CP124522:c4079114-4078872 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References