280825

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4037473..4038023 Replicon chromosome
Accession NZ_CP124522
Organism Salmonella enterica strain PNUSAS118467

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag QJS74_RS19690 Protein ID WP_001199743.1
Coordinates 4037473..4037781 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag QJS74_RS19695 Protein ID WP_001118105.1
Coordinates 4037784..4038023 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS74_RS19670 (4034047) 4034047..4034787 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
QJS74_RS19675 (4034909) 4034909..4035439 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
QJS74_RS19680 (4035762) 4035762..4036895 + 1134 Protein_3847 IS3 family transposase -
QJS74_RS19685 (4036927) 4036927..4037067 - 141 Protein_3848 Arm DNA-binding domain-containing protein -
QJS74_RS19690 (4037473) 4037473..4037781 - 309 WP_001199743.1 CcdB family protein Toxin
QJS74_RS19695 (4037784) 4037784..4038023 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QJS74_RS19700 (4038132) 4038132..4038380 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
QJS74_RS19705 (4038571) 4038571..4039002 - 432 Protein_3852 helix-turn-helix domain-containing protein -
QJS74_RS19715 (4039759) 4039759..4040778 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
QJS74_RS19720 (4040806) 4040806..4041336 - 531 WP_000896758.1 gluconokinase -
QJS74_RS19725 (4041553) 4041553..4042584 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4035854..4038957 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T280825 WP_001199743.1 NZ_CP124522:c4037781-4037473 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT280825 WP_001118105.1 NZ_CP124522:c4038023-4037784 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References