Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4581280..4581898 Replicon chromosome
Accession NZ_CP124517
Organism Escherichia coli strain AVS0343

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QJB09_RS22350 Protein ID WP_001291435.1
Coordinates 4581280..4581498 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QJB09_RS22355 Protein ID WP_000344800.1
Coordinates 4581524..4581898 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB09_RS22315 (4576729) 4576729..4577301 + 573 WP_000779831.1 YbaY family lipoprotein -
QJB09_RS22320 (4577332) 4577332..4577643 - 312 WP_000409908.1 MGMT family protein -
QJB09_RS22330 (4578022) 4578022..4578375 + 354 WP_000878135.1 DUF1428 family protein -
QJB09_RS22335 (4578417) 4578417..4579967 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QJB09_RS22340 (4580131) 4580131..4580601 - 471 WP_000136192.1 YlaC family protein -
QJB09_RS22345 (4580717) 4580717..4581106 - 390 WP_283192240.1 maltose acetyltransferase domain-containing protein -
QJB09_RS22350 (4581280) 4581280..4581498 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QJB09_RS22355 (4581524) 4581524..4581898 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QJB09_RS22360 (4582444) 4582444..4585593 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
QJB09_RS22365 (4585616) 4585616..4586809 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T280802 WP_001291435.1 NZ_CP124517:c4581498-4581280 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT280802 WP_000344800.1 NZ_CP124517:c4581898-4581524 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References