Detailed information of TA system TA280801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4396578..4398267
• Replicon: chromosome
• Accession: NZ_CP124517
• Organism: Escherichia coli strain AVS0343

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJB09_RS21485
• Protein ID: WP_000365807.1
• Coordinates: 4397347..4398267 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJB09_RS21480
• Protein ID: WP_001295795.1
• Coordinates: 4396578..4397360 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJB09_RS21475 (4393196)	4393196..4396294	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJB09_RS21480 (4396578)	4396578..4397360	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJB09_RS21485 (4397347)	4397347..4398267	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJB09_RS21490 (4398432)	4398432..4399208	-	777	WP_000171155.1	site-specific integrase	-
QJB09_RS21495 (4399416)	4399416..4399751	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJB09_RS21500 (4399978)	4399978..4400136	-	159	Protein_4208	integrase	-
QJB09_RS21505 (4400185)	4400185..4400370	+	186	WP_000146240.1	hypothetical protein	-
QJB09_RS21510 (4400585)	4400585..4401199	+	615	WP_001019923.1	YagU family protein	-
QJB09_RS21515 (4401270)	4401270..4401436	+	167	Protein_4211	tail fiber assembly protein	-
QJB09_RS21520 (4401448)	4401448..4401777	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJB09_RS21525 (4402084)	4402084..4402794	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	4390328..4438483	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280801 WP_000365807.1 NZ_CP124517:4397347-4398267 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280801 WP_001295795.1 NZ_CP124517:4396578-4397360 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0