Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2907909..2908709 Replicon chromosome
Accession NZ_CP124517
Organism Escherichia coli strain AVS0343

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag QJB09_RS14465 Protein ID WP_000342452.1
Coordinates 2907909..2908436 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag QJB09_RS14470 Protein ID WP_001277107.1
Coordinates 2908443..2908709 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB09_RS14440 (2902985) 2902985..2903752 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QJB09_RS14445 (2903749) 2903749..2905026 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
QJB09_RS14450 (2905023) 2905023..2905949 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QJB09_RS14455 (2905997) 2905997..2907106 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QJB09_RS14460 (2907529) 2907529..2907912 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
QJB09_RS14465 (2907909) 2907909..2908436 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QJB09_RS14470 (2908443) 2908443..2908709 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QJB09_RS14475 (2908858) 2908858..2909961 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QJB09_RS14480 (2910232) 2910232..2911086 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QJB09_RS14485 (2911331) 2911331..2912389 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
QJB09_RS14490 (2912382) 2912382..2913050 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T280794 WP_000342452.1 NZ_CP124517:c2908436-2907909 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT280794 WP_001277107.1 NZ_CP124517:c2908709-2908443 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References