Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2230056..2230710 Replicon chromosome
Accession NZ_CP124517
Organism Escherichia coli strain AVS0343

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJB09_RS11025 Protein ID WP_000244765.1
Coordinates 2230056..2230463 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJB09_RS11030 Protein ID WP_000354050.1
Coordinates 2230444..2230710 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB09_RS11005 (2226013) 2226013..2227746 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJB09_RS11010 (2227752) 2227752..2228462 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJB09_RS11015 (2228487) 2228487..2229383 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJB09_RS11020 (2229495) 2229495..2230016 + 522 WP_001055874.1 flavodoxin FldB -
QJB09_RS11025 (2230056) 2230056..2230463 - 408 WP_000244765.1 protein YgfX Toxin
QJB09_RS11030 (2230444) 2230444..2230710 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJB09_RS11035 (2230953) 2230953..2231933 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJB09_RS11040 (2232010) 2232010..2232669 - 660 WP_000250275.1 hemolysin III family protein -
QJB09_RS11045 (2232833) 2232833..2233144 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJB09_RS11050 (2233189) 2233189..2234622 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280790 WP_000244765.1 NZ_CP124517:c2230463-2230056 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280790 WP_000354050.1 NZ_CP124517:c2230710-2230444 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References